The U.S. Food and Drug Administration (FDA) approved to market Aczone (dapsone) Gel, 5 per cent for acne vulgaris topical treatment. But patients who have the enzyme deficiency, G6PD (Glucose 6-phosphate dehydrogenase), will need to be monitored with regular blood counts to detect if they are predisposed to one type of anemia (hemolytic anemia). Aczone, a trademark of QLT USA Inc., is an aqueous topical gel which contains 5 per cent dapsone. According to scientific research, combining dapsone in a Solvent Microparticulate (SMP) gel enables dapsone to be applied topically and safely. This product achieved significant per cent reduction in the number of acne lesions and better success rate on the Global Acne Assessment Score in two randomized double-blind, vehicle controlled clinical studies in 3000 acne patients. Oiliness/peeling, dryness, and erythema were the most common adverse events reported from controlled clinical trials. However, there were no significant differences in the adverse event rates between Aczone Gel and vehicle control treated patients. 1.4 per cent of about 3500 patients had the enzyme deficiency -in the Aczone clinical trial program- which is consistent with the incidence in the general North American population. The company QLT will undertake a post-approval Phase IV study in 50 acne patients who have G6PD deficiency and follow them for 6 months, after which QLT expects to submit an application to the FDA to re-evaluate the Aczone label. The President and Chief Executive Officer of QLT Inc., Paul Hastings, stated that “Aczone represents an important clinical advance in dermatology, has demonstrated safety and efficacy in over 4,000 patients. We are very pleased with the FDA’s decision and confident in Aczone’s potential as a new class of treatment for acne patients”.
Archive for ◊ July, 2009 ◊
With the drop in temperature comes a certain dawning, the formation of a certain mood. Most people tend to associate the Holidays with drops in temperature and colder weather, but this is the general comfortable cold and not the frigid chill of deep winter. It is also during these days that normally sane and stable people can end up going into a bit of a panic, with all the last-minute shopping and the “I can’t think of a gift” relatives. For the most part, all this stress and borderline insanity is pretty much worth it once the dust settles. The Holidays, with all the reunions and homecomings that come with them, can be a source of some truly unexpected amounts of stress and anxiety, usually from the same general sources. Students coming home from their first year in college tend to cause quite a bit of pressure and stress on the parents who are going to receive them. There’s quite a bit of getting used to, for one thing. Teenagers coming home from college for the first time have also been away from home for the first time. Having gotten used to living without parental interference, they can often cause a lot of tension when they behave like the independents they perceive themselves to be while the parents would rather still have them under their control. Parents making themselves seem unable to really accept that their child is not the same person that left their home the year before can often end up fighting short bouts of depression, though anger is also a common response. However, defiance of parental authority is not the only aspect of a family relationship that can get stretched during the season. Stress and anxiety also come into play in the preceding days, particularly the period where preparations and gift shopping enter the “critical zone.” There are expectations to be fulfilled and images to maintain, which some Eastern peoples might associate with the concept of “face.” The drive to make sure each and every little detail fits a certain image or projects a certain image that the decorator wants it to can become a major source of stress in some communities. This can be compounded further if the decorator is intent on making things perfect for visiting family members, such as kids who have been off to college or close friends who have been working overseas. All this pressure and over-extending stress is clearly a negative thing. The effects generally pass once the Holidays are over, but certain situations can take time to really sink into the average person. The Holidays are the times when people come home after a prolonged absence and hope to find everything untouched and unchanged from when they left. Yet, they come to realize that they’re not the same people as when they left and little things they missed, like the way their room was decorated or where their favorite little trinket from childhood was placed, have changed. The adjustments can take time because both parties don’t inform each other of these changes, which may seem insignificant to one side, but can have impact on the emotional health of the other.
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When dealing with acne skin care, most of the medical professionals commonly suggest that people affected with acne must practice certain acne skin care methods that will help improve the condition of their skin. Acne, as you may already know, is a very severe skin disorder that affects thousands of people from all over the world. It not only affects the surface of the skin but also the inner layers of the skin. Acne usually occurs on the face, neck, chest and back, and it starts during the adolescence period. During the past several years, a good number of acne experts and skin care professionals have conducted many studies on how to prevent the formation of acne. And fortunately, these skin care specialists have come out with certain acne skin care tips that can be of great help for fighting acne. I have selected the three simpler yet most powerful acne skin care tips that you can follow in order to have a healthier skin. These are mentioned below: Acne Skin Care Tip # 1: You Should Always Clean Your Skin Very Gently First of all, personal hygiene is very necessary for fighting acne. So as what most experts usually suggest, you should gently clean your skin with a mild cleanser at least twice a day. This simple acne skin care step is deemed important for fighting acne since washing your face or the other affected areas will wipe away the acne-causing bacteria found on the skin. Also note that although you are sometimes told to scrub your face, scrubbing is not a good acne skin care move since it will just trigger the development of acne, worsening the condition. In addition to this acne skin care step, it is worth noting that astringents are not always suggested unless the skin is very oily. And, they must only be applied on the oily spots. Acne Skin Care # 2: You Should Refrain from Frequently Holding Your Skin Another helpful acne skin care tip is to avoid frequently handling of the skin. Don’t pinch, pick or squeeze your pimple since it will only worsen the condition. Many of the people have considered this acne skin care step as one of the most important acne skin care pointers knowing that it may only cause infection and scars formation. As this acne skin care tip holds, you should avoid rubbing and touching your skin lesions if possible. Acne Skin Care # 3: Always Choose Cosmetics Carefully This last acne skin care tip holds that people who are being treated for acne must change some of the cosmetics they use. Note that in order to avoid the onset or the development of acne, the cosmetics you plan on using like the foundation, blush, moisturizers, and eye shadow should be oil free. Aside from that, this acne skin care tip also holds that you must avoid oily hair products for they may cause closed comedones. Therefore, those products that are labeled as noncomedogenic should be applied. It is a fact that many of us are very conscious of our skin condition. And as such, we are always wanting to have a fresh, good-looking skin as much as possible. Unfortunately, many of us also fail to come to the conclusion that simple steps are the best ways to accomplish this goal. We often are blind enough that we don’t see what’s really right or wrong for our skin. We often fall in so much frustration and desperation that make us go buy any high-priced beauty products that in the end just turn out to be a waste of time and money, and even worsen our acne. Hopefully, the above mentioned acne skin care tips will be a good start to help you enhance your skin condition.
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Hair threading is becoming more and more popular as individuals search for a new way to remove hair. The process can be done at home if you would like to or you can get a much better procedure done through a salon. For those that are looking for a new method of hair removal, besides all the waxing and the shaving, hair threading may be the answer for you. Although it is about as painful as waxing, it can help to remove the fine hair that grows over your body. You will use normal sewing thread to get the job done. The hair will be removed from the root. For an at home method, try this: Use two feet of sewing thread. Knot the ends to make a large circle. Hold it in both hands and wind it about ten times until it looks like a bow tie. The wound up portion needs to be in the middle. Now, spread the fingers of one hand so that the wound portion moves to the other hand. Practice moving it back and forth for a few minutes. Alternate the fingers that you move, spread and close. Practice first with your leg hairs until you learn how to do it well. Prop one leg up while you sit on a chair. Place the wound side of the thread on one side of the hair and lay the thread from the opposite end around both sides of the hair. Move your fingers as you have been practicing quickly. The hair is captures and pulled from the root. It is often wise to learn how to do hair threading by watching someone else do it. So, perhaps you should invest in a salon procedure the first time so that you can learn. Yes, it hurts a little and yes it is going to need to be done several times, but the process is one way for you to easily fight back unwanted hair. Once you learn how to do it, you will do it better. And, since there are no real risks of using hair threading there is no reason not to enjoy it.
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It is a well known fact that exercise and weight loss make you both look and feel better. Another bit of common knowledge is that to lose weight, control your diet, and exercise regularly gives you a healthier heart. In addition to the previously mentioned benefits of proper diet and exercise are several other very specific health benefits of having a regular exercise and weight loss program. One additional health benefits of exercise and weight loss activities is guarding against osteoporosis, the disease that makes the bones weak and brittle with age. Weight-bearing activities like walking, ellyptical machine, and jogging, have been shown to strengthen the skeletal system and lower the risk of the development of this very debilitating disease. The primary reason for this is that exercises that force the body to bear weight make the bones more dense over time as opposed to a sedentary lifestyle, in which the bones get weaker and more brittle due to a lack of force placed against them. In women in particular, the low estrogen levels that often accomopany menopause and/or very sporadic menstruation make the problem even worse as the bones lose a lot of their mineral content and weaken accordingly. In addition, such activities that many take part in to either lose weight or maintain an already healthy body composition have also been shown to aid in preventing further development of the disease for those who have already been diagnosed and have received clearance from their doctor. To YourBestBody, Lawrence Cole
Your Lifestyle and Fitness Coach
See this Weight Loss Article at YourBestBodyNOW.com
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Increasingly larger numbers of people suffer from heart disease as a consequence of high blood cholesterol levels. There are many factors that enable the accumulation of cholesterol inside the organism, but the major cause is considered to be unhealthy diet. Unhealthy diet and bad eating habits can considerably increase blood cholesterol levels. Cholesterol is produced by the liver and it is required inside the body for fulfilling several roles: cellular protection, hormonal synthesis (testosterone and estrogen), vitamin synthesis and fat digestion. The organism needs very small quantities of cholesterol to sustain its normal activity and inappropriate diet can quickly enable cholesterol to accumulate in excess. The problem with cholesterol is that it can’t be dissolved by the body fluids and it is also difficult to eliminate. When in excess, cholesterol enters the bloodstream and deposits in different places inside the body. Cholesterol can form plaque inside arteries by adhering to the inner arterial walls, causing blockage. If cholesterol deposits inside the coronary arteries (heart arteries), there is a very high risk of heart disease. A healthy diet and appropriate exercise are vital in reducing blood cholesterol levels. It is very important to eat properly, as high cholesterol food can quickly increase blood cholesterol levels. You should consume only low cholesterol foods and products that contain unsaturated fat. Many foods contain high levels of cholesterol: meats, eggs, dairy products, sweets. Also, foods that are rich in saturated fat can also facilitate the accumulation of cholesterol inside the body: organ meats, pork, poultry. Low cholesterol foods should replace foods that contain high quantities of cholesterol and saturated fat. Sweets contain simple carbohydrates which increase body fat deposits and facilitate the accumulation of body cholesterol. It is advised to consume at most 300 mg of cholesterol a day. Considering the fact that a single egg contains around 300 mg of cholesterol, eating properly can be quite tricky. Not at all! You should note that only foods of animal origin contain cholesterol, while vegetal foods are cholesterol free. Although vegetables and fruits contain fat, they actually don’t have any cholesterol. Low cholesterol foods also contain less saturated fat and therefore they are a lot healthier for the organism. It is very difficult to follow a diet based only on fruits and vegetables. To diversify your diet, you can consume low cholesterol foods such as: egg whites, lean meat, fish, chicken. Other low cholesterol foods are skim milk and low-fat yogurt. You should avoid eating fried foods, as they are very unhealthy. Bake or boil low cholesterol foods and eat plenty of vegetable soups. Home-cooked meals should be preferred over supermarket foods. However, if you don’t have time to cook for yourself every day, there are various low cholesterol food products available in supermarkets. It is important to understand that processed, low cholesterol foods available in convenience-stores can actually contain high quantities of saturated fat and they aren’t a very healthy option. Although you can consume such food products once in a while, your diet should be based mainly on healthy, cholesterol free or low cholesterol foods.